A complete list of publications can be found on My NCBI

Endothelial cell signaling in cardiovascular development and disease. Our laboratory helped to establish endoglin functions in non-endothelial cell niches during embryonic development and in adult disease: we established: a functional role for endoglin in vascular smooth muscle cells arising from the neural crest, cell autonomous roles for endoglin in both endothelial and smooth muscle cells of developing blood vessels, and lymphatic vessels.

Tang Y, Urs S, Boucher J, Bernaiche T, Venkatesh D, Spicer DB, Vary CP, Liaw L. Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation. J Biol Chem. 2010;285(23):17556-63. PMCID:2878520.

Mancini ML, Verdi JM, Conley BA, Nicola T, Spicer DB, Oxburgh LH, Vary CP. Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol. 2007;308(2):520-33. PMCID:2041841.

Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP. Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn. 2009;238(10):2670-9. PMCID:2826787.

Mancini ML, Terzic A, Conley BA, Oxburgh LH, Nicola T, Vary CP. Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis. Dev Dyn. 2009;238(10):2479-93. PMCID:2947792.

Novel endoglin-dependent protein expression changes in the vasculature. We contributed to the identification of novel endoglin-dependent functions. Most recently we employed state-of-the-art mass spectrometric approaches to discover and quantify novel endoglin signaling targets, including, endoglin-dependent cancer stromal cell expression of novel proteins such as IGFBP4, and BMP9/endoglin/ALK1-dependent alteration of the SDF1/CXCR4 axis in endothelial cells, conducted in collaboration with Dr. Liaw.

Santibanez JF, Letamendia A, Perez-Barriocanal F, Silvestri C, Saura M, Vary CP, Lopez-Novoa JM, Attisano L, Bernabeu C. Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling. J Cell Physiol. 2007;210(2):456-68.

Jerkic M, Rivas-Elena JV, Santibanez JF, Prieto M, Rodriguez-Barbero A, Perez-Barriocanal F, Pericacho M, Arevalo M, Vary CP, Letarte M, Bernabeu C, Lopez-Novoa JM. Endoglin regulates cyclooxygenase-2 expression and activity. Circ Res. 2006;99(3):248-56.

Young K, Conley B, Romero D, Tweedie E, O’Neill C, Pinz I, Brogan L, Lindner V, Liaw L, Vary CP. BMP9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood. 2012;120(20):4263-73. PMCID:3501721.

Young K, Tweedie E, Conley B, Ames JJ, FitzSimons M, Brooks P, Liaw L, Vary CPH. BMP9 crosstalk with the Hippo pathway regulates endothelial cell matricellular and chemokine responses. PLoS ONE. 2015; Apr 24;10(4):e0122892.