Welcome to the Clinical Trials Office 

As you consider treatment options for yourself or your loved one, you may consider participation in a clinical trial. The resources below provide general and specific information that can help you navigate the clinical trial process.

Current Clinical Trials

Below is a list of enrolling clinical trials at MaineHealth.  Studies can open and close quickly so please contact the Clinical Trials Office directly or speak with your healthcare professional if you are interested in learning more about one of the trials.  You can reach the Clinical Trials Office at 207-396-8670 or email at clinicalresearch@mainehealth.org.

For a complete list of trials open in the U.S. and abroad, visit www.clinicaltrials.gov.

(ATHN Transcends) A Natural History Cohort Study of the Safety Effectiveness, and Practice of Treatment in People with Non-Neoplastic Hematologic Disorders Learn more

(A051701) Randomized Phase II/III Study of Venetoclax (ABT199) Plus Chemoimmunotherapy for MYC/BCL2 Double-Hit and Double Expressing Lymphomas Learn more

(S1826) A Phase III, Randomized Study of Nivolumab (OPDIVO) Plus AVD or Brentuximab Vedotin (ADCETRIS) Plus AVD in Patients (Age >= 12 years) with Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma Learn more

(ASPIRE) A Phase II Multi-institutional Study of Concurrent Radiotherapy, Palbociclib, and Hormone Therapy for Treatment of Bone Metastasis in Breast Cancer Patients (Winship 4472-18) Learn more

(A011801/ COMPASSHER2) The CompassHER2 Trials (Comprehensive Use of Pathologic Response Assessment to Optimize Therapy in HER2-Positive Breast Cancer) CompassHER2 Residual Disease (RD), a Double-Blinded, Phase III Randomized Trial of T-DM1 Compared With T-DM1 and Tucatinib Learn more

(A231901CD/ SharES)  Improving Patient-Centered Communication in Breast Cancer: A RCT of a Shared Decision Engagement System (SHADES) Learn more

(NRG-BR003) A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer Learn more

(NRG-BR004) A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer Learn more

(CCTG MA.39) TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer Learn more

(EA1181) CANCER-BREAST CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy Learn more

(FABREC) Study of Radiation Fractionation on Patient Outcomes After Breast REConstruction (FABREC) for Invasive Breast Carcinoma Learn more

(NOHA in BRCA) A Pilot Study of NOHA levels in BRCA positive Breast Cancer

(NOHA in TNBC) A Pilot Study of NOHA as a monitoring biomarker in triple negative breast cancer (TNBC)

(AALL1821) A Phase 2 Study of Blinatumomab (NSC# 765986) in Combination with Nivolumab (NSC # 748726), a Checkpoint Inhibitor of PD-1, in B-ALL Patients Aged >/= 1 to < 31 Years Old with First Relapse Learn more

(ACNS1831) A Phase 3 Randomized Study of Selumetinib Versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG) Learn more

(ACNS1833) A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine Versus Selumetinib (NSC# 748727) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) Not Associated With BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1) Learn more

(cHOD17) Pediatric Classical Hodgkin Lymphoma Consortium Study: cHOD17 Learn more

(COG AALL1621) A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518, IND# 133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL) Learn more

(COG AALL1631) International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones Learn more

(COG AALL1731) A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy) Learn more

(COG AALL1732) A Phase 3 Randomized Trial of Inotuzumab Ozogamicin (IND#:133494, NSC#: 772518) for Newly Diagnosed High-Risk B-ALL; Risk-Adapted Post-Induction Therapy for High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and Disseminated B-Lly Learn more

(COG AAML1831) A Phase 3 Randomized Trial for Patients with de novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 with GO, and the Addition of the FLT3 Inhibitor Gilteritinib for Patients with FLT3 Mutations Learn more

(COG ACNS1422) A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients Learn more

(COG AGCT1531) A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Learn more

(COG AHEP1531) Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT) Learn more

(COG ALTE11C2) Health Effects After Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy Learn more

(COG ANBL00B1) Neuroblastoma Biology Studies Learn more

(COG ANBL1232) Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients With Non-High-Risk Neuroblastoma Learn more

(COG ANBL1531) A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma (NBL) Learn more

(COG ANHL12P1) A Randomized Phase 2 Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, commercially labeled) in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma (ALCL) IND # 117117 Learn more

(COG APEC14B1) Project: EveryChild Protocol: A Registry, Eligibility Screening, Biology and Outcome Study Learn more

(COG AREN03B2) Renal Tumors Classification, Biology, and Banking Study Learn more

(COG ARST1431) A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating With Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864) in Patients With Intermediate Risk (IR) Rhabdomyosarcoma (RMS) Learn more

(COG AALL1521)  A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway-Mutant Acute Lymphoblastic Leukemia Learn more

(COG AALL1731) A Phase 3 Trial Investigating Blinatumomab ( NSC# 765986) in Combination With Chemotherapy in Patients With Newly Diagnosed Standard Risk or Down Syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients With Localized B-Lymphoblastic Lymphoma (B-LLy) Learn more

(COG NCI Pediatric MATCH) COG Pediatric Molecular Analysis for Therapy Choice Screening Protocol Learn more

(TPX-0005) A Phase 1/2, Open-Label, Safety, Tolerability, Pharmacokinetics, And Anti-Tumor Activity Study Of Repotrectinib In Pediatric And Young Adult Subjects With Advanced Or Metastatic Malignancies Harboring ALK, ROS1, or NTRK1-3 Alterations Learn more

(A221805) Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer Learn more

(EA2182/ DECREASE) A Randomized Phase II Study of De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) Learn more

(S1820) A Randomized Trial of the Altering Intake, Managing Symptoms Intervention for Bowel Dysfunction in Rectal Cancer Survivors Compared to a Healthy Living Education Control: A Feasibility and Preliminary Efficacy Study (AIMS-RC) Learn more

(A021502/Atomic) Randomized Trial of Standard Chemotherapy Alone or Combined With Atezolizumab as Adjuvant Therapy for Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair Learn more

(EA2182/DECREASE) A Randomized Phase II Study of De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) Learn more

(NRG-GI004) Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy With or Without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients With Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer Learn more

(EA2174) A Phase II/III Study of Peri-Operative Nivolumab and Ipilimumab in Patients With Locoregional Esophageal and Gastroesophageal Junction Adenocarcinoma Learn more

(FGCL-3019-087) A Phase 3, Randomized, Double-Blind, Placebo-controlled Study of Pamrevlumab in combination with Gemcitabine Plus Nab-paclitaxel as Neoadjuvant Treatment in Patients with Locally Advanced, Unresectable Pancreatic Cancer Learn more

(NRG-CC007CD) Increasing the Dose of Survivorship Care Planning in Improving Care and Outcomes in Prostate Cancer Survivors Receiving Androgen Deprivation Therapy Learn more

(EV-302) An open-label, randomized, controlled phase 3 study of enfortumab vedotin in combination with pembrolizumab with or without chemotherapy, versus chemotherapy alone in previously untreated locally advanced or metastatic urothelial cancer Learn more

(S1802) Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer Learn more

(S1806) Phase III Randomized Trial of Concurrent Chemoradiotherapy With or Without Atezolizumab in Localized Muscle Invasive Bladder Cancer Learn more

(STEEL/ RTOG-3506) A Trial to See What the Results Are for Radiation Therapy and Hormone Therapy vs Radiation Therapy With Enhanced Hormone Therapy With Enzalutamide for Patients With PSA Recurrence After Surgery (STEEL) Learn more

(GOG-3059) A Phase 3, Randomized, Double-Blind, Adaptive, Placebo/Paclitaxel-Controlled Study of AVB-S6-500 in Combination With Paclitaxel in Patients With Platinum-Resistant Recurrent Ovarian Cancer Learn more

(NRG-GY018) A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer Learn more

(NRG-GY019) A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum Learn more

(NRG-CC008/ SOROCk) A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers Learn more

(NRG-GY009) A Randomized, Phase II/III Study of Pegylated Liposomal Doxorubicin and CTEP-Supplied Atezolizumab Versus Pegylated Liposomal Doxorubicin/Bevacizumab and CTEP-Supplied Atezolizumab Versus Pegylated Liposomal Doxorubicin/Bevacizumab in Platinum Resistant Ovarian Cancer Learn more

(NRG-GY020) A Phase III Randomized Trial of Radiation +/- MK-3475 (Pembrolizumab) for Newly Diagnosed Early Stage High Intermediate Risk Mismatch Repair Deficient (dMMR) Endometrioid Endometrial Cancer Learn more

(GOG 0263/ RTOG 1171) A Randomized Phase III Clinical Trial of Adjuvant Radiation Versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphadenectomy Learn more

(A071801) Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared with Fractionated SRS (FSRS) for Resected Metastatic Brain Disease Learn more

(AG881/ INDIGO) A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled Study of AG-881 in Subjects With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation Learn more

(ChemoID Assay) Standard Chemotherapy Versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients With Recurrent Glioblastoma Multiforme (GBM). Learn more

(NRG-BN003)  Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma Learn more

(NRG-BN007) Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma Learn more

(ON-TRK) ON-TRK: PrOspective Non-interventional study in patients with locally advanced or metastatic TRK fusion cancer treated with larotrectinib Learn more

(RAGNAR) A Phase 2 Study of Erdafitinib in Subjects With Advanced Solid Tumors and FGFR Gene Alterations Learn more

(TRIDENT/ EF-32) EF-32: Randomized, open-label study of Tumor Treating Fields (Optune®, 200kHz) concomitant with radiation therapy and temozolomide for the treatment of newly diagnosed glioblastoma Learn more

(10323/ Moonshot BioBank) Cancer Moonshot Biobank Learn more

(A031704/ PDIGREE) PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated Renal Cell Cancer [PDIGREE] Learn more

(A051901) Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab (Nivo-MR2) Induction Followed by Lenalidomide and Nivolumab Maintenance in Primary CNS Lymphoma Learn more

(Cardio-Surveillance)  Cardio-surveillance of MHCCN Cancer Patients Undergoing Immune Checkpoint Blockade

(DCP-001) Use of a Clinical Trial Screening Tool to Address Cancer Health Disparities in the NCI Community Oncology Research Program (NCORP)

(EA8191/ INDICATE) Phase III Study of PET-Directed Local or Systemic Therapy Intensification in Prostate Cancer Patients With Post-Prostatectomy Biochemical Recurrence Learn more

(ME-CGEC) Maine Cancer Genomics and Genetics Education Core (ME-CGEC): Engaging the Rural End-User in the Development of Treatment Education, Decision & Social Support Tools, with a focus on Cancer Moonshot Biobank (CMB) enrollment and related clinical trials

(NRG-HN005) A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer Learn more

(KRAS G12C) A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation (KRYSTAL-1) Learn more

(EAY-131/ MATCH)  Molecular Analysis for Therapy Choice (MATCH) Learn more

(NCICOVID/ NCCAPS) NCI COVID-19 in Cancer Patients Study (N-CCaPS) : A Longitudinal Natural History Study Learn more

(NHLBI-MDS) The National Myelodysplastic Syndromes Natural History Study Learn more

(S1612) A Randomized Phase II/III Trial of “Novel Therapeutics” Versus Azacitidine in Newly Diagnosed Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS), Age 60 or Older LEAP: Less-Intense AML Platform Trial Learn more

(S1702)  A Phase II Study of Isatuximab (SAR650984) (NSC-795145) for patients with previously treated AL AMYLOIDOSIS Learn more

(TAPUR) TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (TAPUR) Learn more

(WF-1805CD/ HN-STAR) Implementation and Effectiveness Trial of HN-STAR (HN-STAR) Learn more

(A081801/ Alchemist Chemo-IO) Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, ALCHEMIST Chemo-IO Study Learn more

(A151216/Alchemist Screening) Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST) Learn more

(A171901) Older Non-Small Cell Lung Cancer Patients (>/= 70 Years of Age) Treated with First-Line MK-3475 (Pembrolizumab)+/- Chemotherapy (Oncologist’s/ Patient’s Choice) Learn more

(E4512/Alchemist Treatment) A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein Learn more

(EA5181)Randomized Phase III Trial of MEDI4736 (durvalumab) as Concurrent and Consolidative Therapy or Consolidative Therapy Alone for Unresectable Stage 3 NSCLC Learn more

(NRG-LU005) Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase II/III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab Learn more

(LUNGMAP) A Master Protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study) Learn more

(LUNGMAP-S1900A) A Phase II Study Of Rucaparib In Patients With Genomic LOH HIGH And/Or Deleterious BRCA1/2 Mutation Stage IV Or Recurrent Non-Small Cell Lung Cancer (LUNGMAP Sub-Study) Learn more

(S1714) Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer Learn more

(S1827/ MAVERICK) MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer Learn more

(ASTELLAS AKI ASP1128) A Phase 2 Proof of Concept, Double-blind, Randomized, Placebo-controlled Study to Evaluate the
Efficacy of ASP1128 (MA-0217) in Subjects at Risk for Acute Kidney Injury following Coronary Artery Bypass Graft (CABG) and/or Valve Surgery Learn more

(BELIEVE) Behavior of valve Leaflets and the Incidence of reduced mobility post-surgical aortic valve implant Learn more

(Cardiometabolic Study) Molecular Assessment of Human Cardiometabolic Disease

(Mediterranean Diet) A Comparison Of Mediterranean Diet Vs. Standard Diet In CABG Patients On The Cardiac Cell Signaling And Composition Of Lipid Content Learn more

(ON-X 17mm Valve) ON-X® PROSTHETIC HEART VALVE 17mm AORTIC 23mm MITRAL Learn more

(PACES) Anticoagulation for New-Onset Post-Operative Atrial Fibrillation after CABG Learn more

(PROACT Xa) A prospective, randomized, active (warfarin) controlled, parallel-arm clinical trial to determine if patients with an On-X aortic valve can be maintained safely and effectively on the factor Xa inhibitor apixaban Learn more

(REFRESH II) Cytosorb® Reduction Of Free Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery Learn more

(SIRT-CVS)  Short Interval Resveratrol in Cardiovascular Surgery (SIRT-CVS) Trial

(AEGIS II) A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome Learn more

(ARTESiA) Apixaban for the Reduction of Thrombo-Embolism in Patients with Device-Detected Sub-Clinical Atrial Fibrillation Learn more

(EARLY TAVR) Evaluation of Transcatheter Aortic Valve Replacement Compared to SurveilLance for Patients with AsYmptomatic Severe Aortic Stenosis: EARLY TAVR trial Learn more

(ECLIPSE) Evaluation of Treatment Strategies for Severe Calcific Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting Stents Learn more

(ENVISAGE) Clinical Study Protocol Edoxaban Versus Standard Of Care And Their Effects On Clinical Outcomes In Patients Having Undergone Transcatheter Aortic Valve Implantation – In Atrial Fibrillation Edoxaban (DU-176B-C-U4001) ENVISAGE-TAVIAF Learn more

(EVOO) A Multicenter Pilot Study to Evaluate the Effect of EVOO on Lipid Parameters Learn more

(HEART FID) A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Injectafer® (Ferric Carboxymaltose) as Treatment for Heart Failure With Iron Deficiency Learn more

(HERITAGE) Multi-center cross-sectional epidemiological study to characterize the prevalence and distribution of lipoprotein(a) levels among patients with established cardiovascular disease Learn more

(OPTIMIZE) The OPTIMIZE Trial to Assess the Procedural and Clinical Value of the Svelte IDS and RX Sirolimus-Eluting Coronary Stent Systems for the Treatment of Atherosclerotic Lesions in a Randomized Study Learn more

(Philips Ultrasound) Philips Ultrasound Study Protocol – Maine Medical Center

(PROMINENT) Pemafibrate To Reduce Cardiovascular Outcomes By Reducing Triglycerides In Patients With Diabetes Learn more

(Vesailus) Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke  Learn more

(COVID-19 Repository) COVID-19 in MS and Demyelinating Diseases

(NCICOVID/ NCCAPS) NCI COVID-19 in Cancer Patients Study (N-CCaPS):  A Longitudinal Natural History Study Learn more

(NIT-COVID) SARS-CoV-2 Antibody Response and Detection

(Bio-BOOST) Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial (Bio-BOOST) Learn more

(BOOST3) Brain Oxygen Optimization in Severe Traumatic Brain Injury—Phase 3 Learn more

(COBRE PROTECT) Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT): a randomized-controlled trial and microbiome assessment Learn more

(GS-US-540-5912) A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Study Evaluating the Efficacy and Safety of Remdesivir in Participants with Severely Reduced Kidney Function who are Hospitalized for COVID-19 Learn more

(ICECAP) Influence of Cooling duration on Efficacy in Cardiac Arrest Patients Learn more

(MODERNISE) MOderate vs DEep Regimen in NeuroIntensive Care SEdation Learn more

(APPLAUD) A Double-Blind, Randomized, Placebo-Controlled, Phase II Study of the Efficacy and Safety of LAU-7b in the Treatment of Cystic Fibrosis in Adults Learn more

(RESTORE-CF [Translate Bio]) A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Combined Single and Multiple Ascending Dose Study Evaluating the Safety, Tolerability, and Biological Activity of MRT5005 (CO-hCFTR mRNA/ICE LNP) Administered by Nebulization to Adult Subjects with Cystic Fibrosis Learn more

(SIMPLIFY) A protocol to test the impact of discontinuing chronic therapies in people with cystic fibrosis on highly effective CFTR modulator therapy Learn more

(VX19-CFD-003) An Observational Study to Evaluate the Real-world  Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor onthe Burden of Illness in Cystic Fibrosis Patients

(LITE) A pragmatic trial of home versus office based narrow band ultraviolet B phototherapy for the treatment of psoriasis. Short title: Light Treatment Effectiveness (LITE) Study Learn more

(ED-INNOVATION) Emergency Department-Initiated Buprenorphine Validation Network Trial

(ONSD Study) Measuring Optic Nerve Sheath Diameter after Cardiac Arrest: a Pilot Study

(Brown Fat Study) Anti-Diabetic Potential of Exosomes Secreted From Brown Adipose Tissue (BAT) after Bariatric Surgery

(ATHN 8) US Cohort Study of Previously Untreated Patients (PUPs) With Congenital Hemophilia Learn more

(ATHN 9) A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People With Severe Von Willebrand Disease (VWD) Learn more

(ATHN 10) Leveraging the ATHNdataset to Document the State of Rare Coagulation Disorders in the United States

(ATHN 11) An Observational Cohort Study of Long-Term Outcomes of Orthotopic Liver Transplantation in People With Hemophilia Learn more

(Community Counts) CDC Public Health Surveillance for Bleeding Disorders – Registry for Bleeding Disorders Surveillance

(BioPE) Evaluation of Serial Biomarkers in Intermediate Risk Acute Pulmonary Embolism Patients (BioPE)

(ACTIV-4C [MMC]) A multicenter, adaptive, prospective, randomized trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge Learn more

(ACTIV-4C [PBMC]) A multicenter, adaptive, prospective, randomized trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge Learn more

(Early Lyme) Use of Circulating Plasmablasts in the Diagnosis of Early Lyme Disease

(NIT-COVID) SARS-CoV-2 Antibody Response and Detection

(Rural HeART Study) Rural Harm REduction Access and Regional Trends (Rural HeART)

(DART) Decision Aid for Renal Therapy: Promoting Knowledge and Autonomy in Chronic Kidney Disease Patients and their Care-Partners (DART). Learn more

(ACP-103-063) A 16-Week Open-Label Study of the Effects of Treatment With Pimavanserin on Activities of Daily Living in Subjects With Parkinson’s Disease Psychosis Learn more

(BN42082) A phase iiib multicenter, randomized, double-blind, controlled study to evaluate the efficacy, safety and pharmacokinetics of a higher dose of ocrelizumab in adults with relapsing multiple sclerosis Learn more

(BN42083) A phase iiib multicenter, randomized, double-blind, controlled study to evaluate the efficacy, safety and pharmacokinetics of a higher dose of ocrelizumab in adults with primary progressive multiple sclerosis.

(CHARM) Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction Learn more

(COVID-19 Repository) COVID-19 in MS and Demyelinating Diseases

(Evolution RMS2) A Phase III, Multicenter, Randomized, Parallel Group, Double Blind, Double Dummy, Active Controlled Study of Evobrutinib Compared with Teriflunomide, in Participants with Relapsing Multiple Sclerosis to Evaluate Efficacy and Safety Learn more

(HASH4) Neuroinflammatory Response and Headache Control in Patients after Subarachnoid Hemorrhage (HASH4-CSF)Learn more 

(HEP3) Human Epilepsy Project 3: Newly Diagnosed Idiopathic Generalized Epilepsy

(INSYTE) Management of Parkinson’s Disease Psychosis in Actual Practice Learn more

(REALIZE) A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter Trial Of CVL-865 As Adjunctive Therapy In Adults With Drug-Resistant Focal Onset Seizures (REALIZE Trial) Learn more

(RESTORE) A clinical study of patients with symptomatic neurogenic orthostatic hypotension to assess sustained effects of droxidopa therapy Learn more

(SETPOINT2) Stroke-Related Early Tracheostomy versus Prolonged Orotracheal Intubation in Neurocritical care Trial 2 Learn more

(TEMPO-1) A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, 27-Week Trial To Evaluate The Efficacy, Safety, And Tolerability Of Two Fixed Doses Of Tavapadon In Early Parkinson’S Disease (TEMP0-1 Trial) Learn more

(TEMPO-3) A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Flexible-Dose, 27-Week Trial To Evaluate The Efficacy, Safety, And Tolerability Of Tavapadon As Adjunctive Therapy For Parkinson’s Disease In Levodopa-Treated Adults With Motor Fluctuations (TEMP0-3 Trial)

(TEMPO-4)  58-Week Open Label Trial of TAVAPADON In PARKINSON’S Disease (TEMPo-4 TRIAL) Learn more

(Trailblazer) Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer’s Disease Learn more

(XPF-201) A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 as Adjunctive Therapy in Focal-onset Epilepsy Learn more

(XPF-201 Open Label Extension) A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 as Adjunctive Therapy in Focal-onset Epilepsy Learn more

(CREST 2) Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Learn more

(CREST-H) Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis – Hemodynamics (CREST-H) Learn more

(EVOLVE) EndoVascular Treatment Of Wide-Neck Aneurysms, an EvaLuation of Safety and EffectiVeness of Stryker Surpass Evolve™ Flow Diverter System (EVOLVE) Learn more

(Insight) Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

(NANO) Effectiveness and Safety of Small Aneurysm Coiling Trial Learn more

(NeckSpineBAT) Pilot study to identify stem cell populations that give rise to thermogenic brown adipose tissue (BAT) in neck and spine regions of human adults.

(RM-14) Setmelanotide (RM-493) Phase 2 Treatment Trial in Patients with rare genetic disorders of obesity Learn more

(Daily Life) Affect, Thought, and Social context in the Daily Life of Adolescents and Young Adults

(CREST 2) Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Learn more

(CREST-H) Carotid Revascularization and Medical Management for Asymptomatic Carotid stenosis – Hemodynamics (CREST-H) Learn more

(EVAS 1) Prospective, Multicenter, Single Arm Safety and Effectiveness Study of Endovascular Abdominal Aortic Aneurysm Repair Using the Nellix® System: A Pivotal and Continued Access Study Learn more

(MATH VTE) Monotherapy Anticoagulation To expedite Home treatment of venous thromboembolism (MATH VTE) Learn more

(APO) Beta 1-Selective Blockade for Prevention of Postmenopausal Bone Loss: A Phase 3, Multi-Center, Double-Blinded, Randomized Placebo-Controlled Trail Learn more

(CTHRC1) Serum Concentrations of the blood factor Collagen triple helix repeat containing 1 (CTHRC1) in Adult XX Genetic Females with Elevated Serum Testosterone Concentrations: A Pilot Project

(MRG Estradiol) Initial Evaluation of Safety and Efficacy of Administration of Estradiol by Subcutaneous Injections: A Pilot study in Male-to-Female Transgender Patients

LEARN MORE ABOUT CLINICAL TRIALS

Next Step for Providers

Complete our referral form to connect a patient with our oncology clinical trials program.

Next Step for Patients

Complete our patient referral form to learn more about our clinical trials program.

  The MaineHealth Cancer Care Network was awarded a grant by the National Cancer Institute (NCI), as a member of the NCI Community Oncology Research Program (NCORP), to implement a new cancer research program that aims to reach more Mainers in their own cities and towns, ensuring they have access to the best possible patient care, including access to more advanced clinical trials in their home communities.  If you are a patient and thinking about joining a clinical trial, talk to your doctor first.  If you are a provider and would like more information about NCORP, please contact the Clinical Trials Office (contact information below).

Clinical Trials Office

81 Research Drive
Scarborough, Maine 04074

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