MaineHealth’s Institutional Review Board (formerly the Maine Medical Center IRB) is a standing committee responsible for protecting the rights and welfare of people who are subjects in research activities. MaineHealth‘s Human Research Protection Program (HRPP) and policies sets forth the IRB’s basic operational procedures.

All research projects involving human subjects, regardless of the source of funding, require review and approval by an IRB prior to implementation.

MaineHealth’s Human Research Protection Program (HRPP) recognizes that it is a privilege to work with human participants in research and welcomes any information that would support our efforts to assure the continuous quality and compliance of our program.  Submit comments anonymously (your login information will not be collected) by clicking on the button below.

In accordance with federal regulations 45 CFR 46 and 21 CFR 50 and 56, the IRB has the authority to approve, require modifications to, disapprove, terminate or suspend research at participating organizations. The purpose of the IRB is to assure, both in advance and by periodic review that appropriate steps are taken to protect the rights and welfare of humans participating as subjects in research.

To Get Started

If you have a question or need assistance with a research project, we are happy to help. We are available for a phone call or an in-person meeting. Please send an email to to make your request.

If you are a new Investigator or have not completed a Financial Interest Disclosure in the last 12 months, please click the button below.

New Investigators

IRBNetAll IRB Applications, Amendment/Modification Forms, or New Information Forms must be submitted to MaineHealth’s IRB via the “IRBNet” web platform.

To get the answers to most common questions, see the IRBNet Frequently Asked Questions (FAQs). All documents related to IRB submissions can be found in the Document Library within IRBNet. Please DO NOT USE any previously saved IRB forms. The most current forms can be found in the IRB Document Library.

IRBNet Required Steps:

Completion of the following training is required in order to access or submit research projects to the MaineHealth IRB.  Please feel free to contact the IRB office for any questions:



The New User Registration Instructions “Energizer” can be viewed here.


LINK to CITI program website:

Link to CITI Account [pdf]


Attach Credentials to your User Profile:

How to Manage Training & Credentials


New Project Training

The New Project Submission training resources walk researchers and study coordinators through the five steps of submitting a new project.

Login: mmc/ Password: training

Video [9 min]

New Project Submission Training [pdf]


Post-Submission Training

Post-Submission Advanced Topics training demonstrate the IRBNet messaging structure, how to successfully update project documents and submit a subsequent (ex. Modifications Required) package to a committee and other topics.

Login: mmc/ Password: training

Video [7 min]

Post-Submission Advanced Topics Training [pdf]

Subsequent Packages [pdf]

Institutional Review Board

1 Riverfront Plaza
Westbrook, Maine 04092