Patrizia Roy, PhD
Technology Manager
Education
MS: Biology, University of Hamburg, Germany
PhD: Molecular Biology, University of Hamburg, Germany
Appropriate levels of thyroid hormones are especially crucial during early developmental stages as well as later in life. Among other diseases changes in thyroid hormone levels have been linked to many different neurological and behavioral disorders, including muscle weakness, impaired memory, anxiety, and depression. My research interests focus on the effects of altered thyroid hormones for the brain during development and later on in the adult and their consequences on behavior.
Increased Aggression and lack of Maternal Behavior in DIO3-Deficient Mice are Associated with Abnormalities in Oxytocin and Vasopressin Systems. Stohn JP, Martinez ME, Zafer M, Lopez-Espindola D, Keyes LM, Hernandez A.Genes, Brain and Behavior. 2017 Aug 4. doi: 10.1111/gbb.12400.
Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Jin, Y-R, Stohn JP, Wang Q, Nagano K, Baron R, Bouxsein ML, Rosen CJ, Adarichev VA, Lindner V. Bone. 2017 Jan 21; 97:153-167. doi.org/10.1016/j.bone.2017.01.022.
Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism. Stohn JP, Martinez, ME, Hernandez A. Psychoneuroendocrinology. 2016 Aug. doi: 10.1016/j.psyneuen.2016.08.021
MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated with the Absence of a Functional Type 3 Deiodinase. Stohn JP, Martinez ME, Matoin K, Morte B, Bernal J, Galton VA, St Germain D, Hernandez A. Endocrinology. 2016 Aug; 157(8):3266-77. doi: 10.1210/en.2016-1162.
The Type 3 Deiodinase Is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis. Martinez ME, Karaczyn A, Stohn JP, Donnelly WT, Croteau W, Peeters RP, Galton VA, Forrest D, St Germain D, Hernandez A. Endocrinology. 2016 Mar; 157(3):1276-88. doi: 10.1210/en.2015-1910. Epub 2016 Jan 4.
Cthrc1 controls adipose tissue formation, body composition, and physical activity. Stohn JP, Wang Q, Siviski ME, Kennedy K, Jin YR, Kacer D, DeMambro V, Liaw L, Vary CP, Rosen CJ, Prudovsky I, Lindner V. Obesity (Silver Spring). 2015 Aug; 23(8):1633-42. doi: 10.1002/oby.21144. Epub 2015 Jul 7.
Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors. Duarte CW, Stohn JP, Wang Q, Emery IF, Prueser A, Lindner V. PLoS One. 2014 Jun 19; 9(6):e100449. doi: 10.1371/journal.pone.0100449. eCollection 2014.
Cthrc1, a novel circulating hormone regulating metabolism. Stohn JP, Perreault NG, Wang Q, Liaw L, Lindner V. PLoS One. 2012; 7(10):e47142. doi: 10.1371/journal.pone.0047142. Epub 2012 Oct 8.