A complete list of publications can be found on My NCBI

Jafari A, Fairfield H, Andersen T, Reagan MR. Myeloma-bone marrow adipocyte axis in tumor survival and treatment response. British Journal of Cancer. Br J Cancer. 2021 Apr 15. doi: 10.1038/s41416-021-01371-4. Online ahead of print. PMID: 33859343.

Costa S, Fairfield H, Farrell M, Murphy C, Soucy A, Holdsworth G, Reagan MR. Sclerostin antibody increases trabecular bone and bone mechanical properties by increasing osteoblast activity damaged by whole-body irradiation in mice. Bone. 2021 Mar 16;147:115918. doi: 10.1016/j.bone.2021.115918. Online ahead of print.PMID: 33737193

Fairfield H, Costa S, Falank C, Farrell M, Driscoll H, Reagan MR. Multiple myeloma cells inhibit adipogenesis, increase senescence-related and inflammatory gene transcript expression, and alter metabolism in preadipocytes. Frontiers in Oncology. 2021 Feb 18;10:584683. doi: 10.3389/fonc.2020.584683. PMID: 33680918

Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR. Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype. Cancer Research 2020 Nov 20. doi: 10.1158/0008-5472.CAN-20-1088. PMID: 33218968

Fairfield H, Costa S, DeMambro V, Schott C, Martins JDS, Ferron M, Vary C, Reagan MR. Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification. JBMR Plus. 2020 Oct 14;4(11):e10413. doi: 10.1002/jbm4.10413

Reagan MR, Fairfield H and Clifford Rosen. Bone Marrow Adipocytes: A Link between Obesity and Bone Cancer. Cancers. 2021. 13(3),364.https://doi.org/10.3390/cancers13030364

Farrell M, Fairfield H, Costa S, D’Amico A, Falank C, Brooks DJ, Reagan MR. Sclerostin-Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters. J Bone Miner Res. 2020 Aug 26. doi: 10.1002/jbmr.4170. PMID: 32845528

Patil PP, Reagan MR, Bohara RA. Int J Biol Macromol. Silk fibroin and silk-based biomaterial derivatives for ideal wound dressings. 2020 Aug 16:S0141-8130(20)34128-3. doi: 10.1016/j.ijbiomac.2020.08.041. PMID: 32814099

Kreeger PK, Brock A, Gibbs HC, Grande-Allen KJ, Huang AH, Masters KS, Rangamani P, Reagan MR, Shannon L. Servoss. Ten Simple Rules for Women Principal Investigators During a Pandemic. PLOS Computational Biology. 2020 oct 29; 16(10):e1008370. doi: 10.1371/journal.pcbi.1008370. PMID: 33119585; PMCID: PMC7595267.

Reagan MR. Critical Assessment of In Vitro and In Vivo Models to Study Marrow Adipose Tissue. Curr Osteoporos Rep. 2020 Apr;18(2):85-94. doi: 10.1007/s11914-020-00569-4. PubMed PMID: 32124181; PubMed Central PMCID: PMC7189908.

Sarkar S, Chauhan SKS, Daly J, Natoni A, Fairfield H, Henderson R, Nolan E, Swan D, Hu J, Reagan MR, O’Dwyer M. The CD38^lownatural killer cell line KHYG1 transiently expressing CD16^F158V in combination with daratumumab targets multiple myeloma cells with minimal effector NK cell fratricide. Cancer Immunol Immunother. 2020 Mar;69(3):421-434. doi: 10.1007/s00262-019-02477-8. Epub 2020 Jan 9. PubMed PMID: 31919623; PubMed Central PMCID: PMC7133790.

Natoni A, Farrell ML, Harris S, Falank C, Kirkham-McCarthy L, Macauley MS, Reagan MR, O’Dwyer M. Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model. Haematologica. 2020;105(2):457-467. doi: 10.3324/haematol.2018.212266. PubMed PMID: 31101754; PubMed Central PMCID: PMC7012485.

Murphy CS, Liaw L, Reagan MR. In vitrotissue-engineered adipose constructs for modeling disease. BMC Biomed Eng. 2019;1. doi: 10.1186/s42490-019-0027-7. Oct 29. PubMed PMID: 32133436; PubMed Central PMCID: PMC7055683.

McDonald MM, Reagan MR, Youlten SE, Mohanty ST, Seckinger A, Terry RL, Pettitt JA, Simic MK, Cheng TL, Morse A, Le LMT, Abi-Hanna D, Kramer I, Falank C, Fairfield H, Ghobrial IM, Baldock PA, Little DG, Kneissel M, Vanderkerken K, Bassett JHD, Williams GR, Oyajobi BO, Hose D, Phan TG, Croucher PI. Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma. Blood. 2017; 129(26):3452-3464. PMID: 28515094.

Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M. Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature. 2017; 546(7656):107-112. PMID: 28538730.

Soley L, Falank C, Reagan MR. MicroRNA Transfer Between Bone Marrow Adipose and Multiple Myeloma Cells. Current osteoporosis reports.  2017; 15(3):162-170. PMID: 28432594.

Fairfield H, Rosen CJ, Reagan MR. Connecting Bone and Fat: The Potential Role for Sclerostin.Current molecular biology reports. 2017; 3(2):114-121. NIHMSID: NIHMS869329 PMID: 28580233 PMCID: PMC5448707.

Sacco A, Kawano Y, Moschetta M, Zavidij O, Huynh D, Reagan MR, Mishima Y, Manier S, Park J, Morgan E, Takagi S, Wong KK, Carrasco R, Ghobrial IM, Roccaro AM. A novel in vivo model for studying conditional dual loss of BLIMP-1 and p53 in B-cells, leading to tumor transformation.  American journal of hematology. 2017; PMID: 28474779.

McDonald MM, Fairfield H, Falank C, Reagan MR. Adipose, Bone, and Myeloma: Contributions from the Microenvironment. Calcified tissue international. 2017; 100(5):433-448. NIHMSID: NIHMS858417. PMID: 27343063. PMCID: PMC5396178.

Fairfield H, Falank C, Harris E, Demambro V, McDonald M, Pettitt JA, Mohanty ST, Croucher P, Kramer I, Kneissel M, Rosen CJ, Reagan MR. The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. Journal of cellular physiology. 2017; PMID:  28460416

Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O’Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM. Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia. 2017;  PMID: 28344315

Goldstein RH*, Reagan MR*, Anderson K, Kaplan DL, and Rosenblatt M. Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and can promote bone metastasis. *Co-first authorship. Cancer Res. 2010; 70(24):10044-50. PMCID: PMC3017423.

Reagan MR, Kaplan DL. Concise review: Mesenchymal stem cell tumor-homing: detection methods in disease model systems. Stem Cells. 2011; 29(6):920-7. PMID: 21557390.

Reagan MR, Seib P, Sage E, McMillin D, Janes S, Mitsiades C, Kaplan DL. Cell-Based Anti-Cancer Implant Systems: TRAIL-Mesenchymal Stem Cells and Silk Scaffolds. J Breast Cancer. 2012;15(3):273-82. PMCID: PMC3468780.

Reagan, MR and Ghobrial IM. Multiple Myeloma-Mesenchymal Stem Cells: Characterization, Origin, and Tumor-Promoting Effects. Clin Cancer Res. 2012; 18(2):342-9. PMCID: PMC3261316.

Roccaro A, Sacco A, Maiso P, Azab A, Tai Y, Reagan MR, Azab F, Flores L, Campigotto F, Weller E, Anderson KC, Scadden D, Ghobrial I. Bone marrow mesenchymal stromal cell-derived exosomes support multiple myeloma pathogenesis. J Clin Invest. 2013;123(4):1542-55. PMCID: PMC3613927.

Glavey SV, Manier S, Natoni A, Sacco A, Moschetta M, Reagan MR, Murillo LS, Sahin I, Wu P, Mishima Y, Zhang Y, Zhang W, Zhang Y, Morgan G, Joshi L, Roccaro AM, Ghobrial IM, O’Dwyer ME.. The Sialyltransferase ST3GAL6 Influences Homing and Survival in Multiple Myeloma. Blood. 2014; Epub Ahead of print. PMID: 25061176

Swami A* & Reagan MR*, Basto P, Mishima Y, Kamaly N, Glavey S, Zhang S, Moschetta M, Seevaratnam D; Zhang Y, Liu J, Memarzadeh T, Wu J, Manier S, Shi J, Bertrand N, Lu ZN, Nagano K, Baron R, Sacco A, Roccaro AM, Farokhzad OC, Ghobrial IM. Engineered Nanomedicine for Myeloma and Bone Microenvironment Targeting. PNAS. 2014;111(28):10287-92. *Co-first authorship. PMCID: PMC4104924.

Reagan MR, Mishima Y, Glavey S, Zhang Y, Manier S, Lu ZN, Memarzadeh M, Zhang Y, Sacco A, Aljawai Y, Tai Y-T, Ready JE, Shi J, Kaplan DL, Roccaro AM, Ghobrial IM. Investigating osteogenic differentiation in Multiple Myeloma using a novel 3D bone marrow niche model. Blood. 2014; 124(22):3250-9. PMCID: PMC4239334.

Roccaro AM, Sacco A, Purschke WG, Moschetta M, Buchner K, Maasch C, Zboralski D, Zöllner S, Vonhoff S, Mishima Y, Maiso P, Reagan MR, Lonardi S, Ungari M, Facchetti F, Eulberg D, Kruschinski A, Vater A, Rossi G, Klussmann S, Ghobrial IM. SDF-1 inhibition targets the bone marrow niche for cancer therapy. Cell Reports. 2014; 9(1):118-28. PMCID: PMC4194173

Reagan MR, Liaw L, Rosen CJ & Ghobrial IM. Dynamic Interplay between Bone and Multiple Myeloma: Emerging Roles of the Osteoblast. Bone. 2015;75:161-169. PMID: 25725265