M-COBRE News, Timeline & Photos
Timeline
Congratulations to Principal Investigator Dr. Anyonya Guntur. His COBRE Project work is entitled: “The essential role for mitophagy in osteoblast differentiation.”
The monthly meeting featured Dr. Johnson Liu. Dr. Liu lead a clinical-translational round table discussion on general hematology (anemia, thrombocytopenia, disorders of coagulation), bone marrow failure syndromes, myelodysplastic syndromes, acute and chronic leukemia, and multiple myeloma.
Dr. Joe Nadeau joins MaineHealth Institute for Research as a Faculty Scientist III in the Center for Molecular Medicine. Dr. Nadeau will also be the Chairperson for the Metabolic COBRE Steering Committee.
Principal Investigator: Dr. Robert Friesel Title: Spry1 regulation of PDGFR-induced adipose tissue fibrosis
Principal Investigator: Dr. Kimberly Malka Title: Characterization of the Microenvironment Involved in Aortic Pathologies
Principal Investigator: Dr. Igor Prudovsky Title: CTHRC1 anti-adipogenic signaling
The monthly meeting featured Drs. Esther Shao and Suni Malhotra. There was discussion on some of the clinical problems faced by patients with complex congenital heart disease.
COBRE Annual Retreat, July 30-31, External Advisory Board Left to right: Pamela Duncan, Evan Rosen, Tom Clemens, Cliff Rosen, Gerard Karsenty, Lucy Liaw.
Dr. Kilby discussed fatty liver/steatohepatitis, its clinical significance, and where the field of gastroenterology is going with regard to its diagnosis and management.
Dr. Michael Pinette, Maternal-Fetal Medicine, MaineHealth, led a round table discussion on fetal development.
Dr. Jeffery Rosenblatt presented on Cardiac Molecular Imaging
Dr. Michaela Reagan, was at Capitol Hill with fellow American Society for Bone & Mineral Research (ASBMR) members advocating for NIH funding and bills that support bone health.
Dr. Cal Vary’s research was published in Molecular Cancer Research: Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells
Dr. Michaela Reagan’s research was published in Frontiers In Endocrinology: Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma and JBMRPlus: Multiple Myeloma and Fatty Acid Metabolism
Dr. John Vella, MaineHealth, Nephrology. Dr. Vella visited to generate a discussion on the effects of kidney disease (early dysfunction to uremia) on metabolism and to engage in a conversation describing patients with kidney disease through the eyes of the clinician and sharing what gaps in knowledge in Nephrology provide the greatest vexation for the Nephrologist.
Dr. Aaron Brown’s research was published in Cell Reports: A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome
Principal Investigator: Dr. Ilka Pinz & Dr. Doug Sawyer Title: A Comparison of Cardiac Lipid Composition in CABG Patients on Mediterranean vs. Standard diet
Dr. Sarah Hallen, Geriatric Medicine, MaineHealth. Dr. Hallen visited to generate a discussion with researchers about The Frailty Phenotype: Clinical Implications of Homeostenosis. Participants also engaged with her around the tissue changes that occur with aging and their implications for clinical frailty, the effect of aging on the brain, blood-brain barrier permeability and their clinical effects.
Principal Investigator: Dr. Larisa Ryhzova Title: Comparison of Cas9 mRNA Versus Cas9 Protein for Effective Genome Modification in the Mouse
The Proteomics and Lipidomics Core facility welcomed new hire, Kieran Wynne.












