Aaron Brown, PhD
Faculty Scientist I
Center for Molecular Medicine
Brown Lab
Understanding how fat tissue burns energy to reveal new therapeutic avenues directed at reversal of obesity-related diseases such as type 2 diabetes, stroke and heart disease.
A complete list of publications can be found on My NCBI
Doucette CC, Nguyen DC, Barteselli D, Blanchard S, Pelletier M, Kesharwani D, Jachimowicz E, Su S, Karolak M, Brown AC. Optogenetic activation of UCP1-dependent thermogenesis in brown adipocytes. iScience. 2023 Apr 1;26(4):106560. doi: 10.1016/j.isci.2023.106560. PMID: 37123235; PMCID: PMC10139976.
Brown AC, Insights into the adipose stem cell niche in health and disease. Academic Press – Scientific Principles of Adipose Stem Cells. 2022, Chapter 4, Pages 57-80.
Butts JC, Martino J, Brown AC. Insights into current models for developing brown adipocytes from induced pluripotent stem cells. Book chapter. Academic Press – Current Progress in iPSC-derived Cell Types, 2021, 95-115.
Brown AC. Brown adipocytes from induced pluripotent stem cells-how far have we come? Ann N Y Acad Sci. 2020 Mar;1463(1):9-22. doi: 10.1111/nyas.14257. Epub 2019 Oct 1. PMID: 31573081; PMCID: PMC7078043.
Brown AC, Gupta AK, Oxburgh L. Long-Term Culture of Nephron Progenitor Cells Ex Vivo. Methods Mol Biol. 2019;1926:63-75. doi: 10.1007/978-1-4939-9021-4_6. PubMed PMID: 30742263.
Su S, Guntur AR, Nguyen DC, Fakory SS, Doucette CC, Leech C, Lotana H, Kelley M, Kohli J, Martino J, Sims-Lucas S, Liaw L, Vary C, Rosen CJ, Brown AC. A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome. Cell Reports. Featured article. 2018 Dec 11;25(11):3215-3228.
Blocking FSH induces thermogenic adipose tissue and reduces body fat. Liu P, Ji Y, Yuen, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown AC, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M. Nature. 2017 Jun 1;546(7656):107-112. Read Abstract
Growth Factor Regulation in the Nephrogenic Zone of the Developing Kidney. Oxburgh L, Muthukrishnan SD, Brown AC. Results Probl Cell Differ. 2017;60:137-164 Read Abstract
Brown AC, Muthukrishnan S, Oxburgh L. A Synthetic Niche for Nephron Progenitor Cells. Developmental Cell. 2015 Jul 27;34(2):229-41.
Yuwen Li, Jiao Liu, Wencheng Li, Aaron Brown, Melody Baddoo, Marilyn Li, Thomas Carroll, Leif Oxburgh, Yumei Feng, and Zubaida Saifudeen. p53 Enables Metabolic Fitness and Self-Renewal of Nephron Progenitor Cells. Development. 2015 Apr 1;142(7):1228-41
Fetting JL, Guay JA, Karolak MJ, Iozzo RV, Adams DC, Maridas DE, Brown AC, Oxburgh L. FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development. 2014 Jan;141(1):17-27.
Leif Oxburgh, Aaron C. Brown, Deepthi Muthukrishnan, Jennifer L. Fetting. Bone morphogenetic protein signaling in nephron progenitor cells. Pediatric nephrology. 2013 Aug 20.
Brown AC, Muthukrishnan S, Guay JA, Adams DC, Schafer DA, Fetting JL, Oxburgh L. Role for compartmentalization in nephron progenitor differentiation. PNAS. 2013. Mar 19;110(12):4640-5.
Brown AC, Adams DC, de Caestecker M, Yang X, Friesel R, Oxburgh L. FGF/EGF signaling regulates self renewal of renal progenitor cells during embryonic development. Development. 2011;138,5099-5112.
Brown AC, Blank U, Adams DC, Karolak MJ, Fetting JL, Hill BL, Oxburgh L. Isolation and culture of cells from the nephrogenic zone of the embryonic mouse kidney. J Vis Exp. 2011 Apr 22;(50).
Oxburgh L, Brown AC, Fetting J, Hill B. BMP signaling in the nephron progenitor niche. Pediatr Nephrol. 2011 Mar 4.
Blank U, Brown AC, Adams DC, Karolak MJ, Oxburgh L. BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development. 2009;136(21):3557-66.