Igor Prudovsky, PhD, DSc
Faculty Scientist II
Center for Molecular Medicine

Damien Carter, MD
Critical Care Surgeon
Maine Medical Center

Prudovsky Lab & Tissue Repair and Regeneration Program

The Prudovsky laboratory studies molecular mechanisms underlying tissue repair.

The Tissue Repair and Regeneration Program is a collaboration between Drs. Prudovsky and Carter.  This work brings together basic or bench science (Prudovsky Lab) and the clinical expertise in the area of burn trauma (Dr. Carter) to develop a better understanding of tissue repair and regeneration.

A complete list of publications can be found on My NCBI

Kacer D, Machnitzky E, Fung A, Greene A, Carter D, Rappold J, Prudovsky I. Anti-fibrinolytic agent tranexamic acid suppresses the endotoxin-induced Tnfa and Il1a genes in plasmin-independent manner. Transfusion 2023 Suppl.3: S168-S176. PMID 37070378.

Prudovsky I, Kacer D, Zucco VV, Palmeri M, Falank C, Kramer R, Carter D, Rappold J.  Tranexamic acid: Beyond antifibrinolysis.Transfusion. 2022 Aug;62 Suppl 1:S301-S312. doi: 10.1111/trf.16976. Epub 2022 Jul 14.

Prudovsky I. Cellular Mechanisms of FGF-Stimulated Tissue Repair. Cells. 2021, 10 (7):1830.

Yin H, Favreau-Lessard AJ, deKay JT, Herrmann YR, Robich MP, Koza RA, Prudovsky I, Sawyer DB, Ryzhov S. Protective role of ErbB3 signaling in myeloid cells during adaptation to cardiac pressure overload. J Mol Cell Cardiol. 2021, 152: 1-16.

Robich M, Ryzhov S, Kacer D, Palmeri M, Peterson SM, Quinn RD, Carter D, Sheppard F, Hayes T, Sawyer DB, Rappold J, Prudovsky I, Kramer RS. Prolonged Cardiopulmonary Bypass is Associated With Endothelial Glycocalyx Degradation. J Surg Res. 2020, 251:287-295.

Keeley T, Kirov A, Koh WY, Demambro V, Bergquist I, Cotter J, Caradonna P, Siviski ME, Best B, Henderson T, Rosen CJ, Liaw L, Prudovsky I, Small DJ.  Resistance to visceral obesity is associated with increased locomotion in mice expressing and endothelial specific fibroblast growth factor 1 transgene. Physiol Rep. 2019 Apr;7(7):e14034.

Prudovsky I, Carter D, Kacer D, Palmeri M, Soul T, Kumpel C, Pyburn K, Barrett K, DeMambro V, Alexandrov I, Brandina I, Kramer R, Rappold J. Tranexamic acid suppresses the release of mitochondrial DNA, protects the endothelial monolayer and enhances oxidative phosphorylation. J Cell Physiol. 2019, 234, 19121-19.

Carter DW, Prudovsky I, Kacer D, Soul T, Kumpel C, Pyburn K, Palmeri M, Kramer R, Rappold   Tranexamic acid suppresses the release of mitochondrial DAMPs and reduces lung inflammation in a murine burn model. J Trauma Acute Care Surg. 2019, 86:617-624.

Prudovsky I, Anunciado-Koza R, Jacobs CG, Kacer D, Siviski ME and Koza RA. Mesoderm specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy. J Cellular Biochemistry. 2018, 119:2636-45.

Liaw L, Prudovsky I, Koza RA, Anunciado-Koza RV, Siviski ME, Lindner V, Friesel RE, Rosen CJ, Baker PR, Simons B, Vary CP. Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships with Mouse Adipose Tissues. J Cellular Biochemistry. 2016, 117, 2182-93.

Talukder HMA, Preda M, Rhyzova L, Prudovsky I, Pinz IM. Heterozygous caveolin-3 mice show increased susceptibility to palmitate-induced insulin resistance. Physiology Reports. 2016,4, pii: e12736. doi: 10.14814/phy2.12736.

Prudovsky I, Kacer D, Davis J, Shah V, Jayanthi S, Huber I, Dakshinamurthy R, Ganter O, Soldi R, Neivandt D, Guvench O, Suresh Kumar TK. Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release. Biochemistry. 2016: 1159-67.

Poole A, Kacer D, Cooper E, Tarantini F, Prudovsky I. Sustained Inhibition of Proliferative Response After Transient FGF Stimulation is Mediated by Interleukin 1 Signaling. J Cellular Physiol.  2016, 231:650-8.

Prudovsky I, Kacer D, Davis J, Shah V, Jayanthi S, Huber I, Dakshinamurthy R, Ganter O, Soldi R, Neivandt D, Guvench O, Suresh Kumar TK. Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release. Biochemistry. 2016, 55:1159-67.

Stohn P, Wang Q, Siviski M, Kennedy K, Jin J-R, Kacer D., DeMambro V, Liaw L, Vary, C, Rosen C., Prudovsky I, Lindner V. Cthrc1 controls adipose tissue formation, body composition and physical activity. Obesity. 2015, 23; 1633-42.

Kirov A, Kacer D, Conley BA, Vary CP, Prudovsky I. AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway. Journal of cellular biochemistry. 2015; 116(8):1522-31. PubMed [journal] PMID: 25560297.

Poole A, Knowland N, Cooper E, Cole R, Wang H, et al. Transitory FGF treatment results in the long-lasting suppression of the proliferative response to repeated FGF stimulation. Journal of cellular biochemistry. 2014; 115(5):874-88. NIHMSID: NIHMS632532 PubMed [journal] PMID: 24375433, PMCID: PMC4205782.

Wang T, Green LA, Gupta SK, Kim C, Wang L, et al. Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction. PloS one. 2014; 9(3):e91063. PubMed [journal] PMID: 24608713, PMCID: PMC3946685.

Danza G, Di Serio C, Ambrosio MR, Sturli N, Lonetto G, et al. Notch3 is activated by chronic hypoxia and contributes to the progression of human prostate cancer. International journal of cancer. Journal international du cancer. 2013; 133(11):2577-86. NIHMSID: NIHMS486217 PubMed [journal] PMID: 23729168, PMCID:PMC3788097.

Gong Y, Yang X, He Q, Gower L, Prudovsky I, et al. Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src. Angiogenesis. 2013; 16(4):861-75. NIHMSID: NIHMS516697 PubMed [journal] PMID: 23955631, PMCID: PMC3790316.

Sterling SM, Allgeyer ES, Fick J, Prudovsky I, Mason MD, et al. Phospholipid diffusion coefficients of cushioned model membranes determined via z-scan fluorescence correlation spectroscopy. Langmuir : the ACS journal of surfaces and colloids. 2013; 29(25):7966-74. NIHMSID: NIHMS487973 PubMed [journal] PMID: 23705855, PMCID: PMC3758428.

Prudovsky I. Nonclassically Secreted Regulators of Angiogenesis. Angiology: open access. 2013; 1(1):1000101. NIHMSID: NIHMS549087 PubMed [journal] PMID: 24511556, PMCID: PMC3914728.

Prudovsky I, Kumar TK, Sterling S, Neivandt D. Protein-phospholipid interactions in nonclassical protein secretion: problem and methods of study. International journal of molecular sciences. 2013; 14(2):3734-72. PubMed [journal] PMID: 23396106, PMCID: PMC3588068.

Lopez-Castejon G, Luheshi NM, Compan V, High S, Whitehead RC, et al. Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome. The Journal of biological chemistry. 2013; 288(4):2721-33. PubMed [journal] PMID: 23209292, PMCID: PMC3554938.

Prudovsky I, Vary CP, Markaki Y, Olins AL, Olins DE. Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes. Nucleus (Austin, Tex.). 2012; 3(2):200-10. PubMed [journal] PMID: 22555604, PMCID: PMC3383575.

Kirov A, Al-Hashimi H, Solomon P, Mazur C, Thorpe PE, et al. Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1. Journal of cellular biochemistry. 2012; 113(3):956-66. NIHMSID: NIHMS333359 PubMed [journal] PMID: 22034063, PMCID: PMC3264788.