Furthering our understanding of the brain-bone-metabolism connection.
The Motyl laboratory is broadly interested in how the nervous system regulates bone turnover. Bone is a dynamic tissue, which is constantly being broken down (bone resorption) and rebuilt (bone formation). Many local and systemic factors regulate bone turnover, including signals from the nervous system. We have specific interests in understanding the role of bone-resorbing osteoclasts in neural-mediated bone changes, and identifying feedback loops regulating neural output to bone. Our work has implications for the natural aging process, as well as for people taking medications that influence the central nervous system, like β-blockers and opioids.