Lucy Liaw, PhD
Faculty Scientist III
Center for Molecular Medicine
Liaw Lab
Tackling cardiometabolic disease
Lucy Liaw, PhDFaculty Scientist III Education I have run a research program at Maine Medical Center for over 20 years, focusing on understanding regulators of cardiovascular disease. My current responsibilities also include overseeing our Mouse Genome Modification shared resource and directing our Research Training programs. I also lead a Center of Biomedical Research Excellence in Metabolic Networks, and in this capacity mentor early career investigators and oversee additional shared resources. I am inspired by my outstanding research team and all of the other dedicated individuals that it takes to run a successful research operation |
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Anne Harrington, BS
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Abby Kaija
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Maryam Mahdi
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Kimberly Malka, MD, PhDVascular Surgeon |
Larisa Ryzhova, MD, PhDScientific Manager |
Xuehui YangStaff Scientist My research interest is to elucidate the mechanisms of pathogenesis of cardiovascular diseases. My focus is on the regulation of vascular smooth muscle cell (VSMC) phenotypic remodeling.VSMCs are localized in the tunica media of the vasculature and responsible for regulating arterial tone, blood pressure, and blood supply of the tissues. However, under pathological or stressed conditions, VSMCs undergo phenotypic switching, and contribute to multiple cardiovascular diseases such as atherosclerosis, hypertension and arterial aneurysms. My goal is to identify disease related VSMC phenotypes, and the underlying signaling pathways. Caption photo left: Multicolor RNA Scope analysis for Spry1, PDGFRb, and Sca1 mRNA expression demonstrates a colonial VSMC up-regulation of Sca1, a mesenchymal marker, under hypercholesterolemia condition in SMC-specific Spry1 knockout mice. White arrowheads indicate Sca1 expressing VSMC in vessel media layer |