Robert Koza, PhD
Faculty Scientist III
Center for Molecular Medicine
Koza Lab
Identifying non-genetic based molecular pathways which can regulate the development of obesity and type 2 diabetes.
A complete list of publications can be found on My NCBI
Koza, R.A., U.C. Kozak, L.J. Brown, E.H. Leiter, M.J. MacDonald, and L.P. Kozak. Sequence and tissue-dependant RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase. Arch. Biochem. Biophys. 336: 97-104, 1996. PMID: 8951039
Guerra, C., R.A. Koza, H.H. Yamashita, K.W. King, and L.P. Kozak. Emergence of brown adipocytes in white fat is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102: 412-420, 1998. PMCID: PMC508900
Koza, R.A., S.M. Hohmann, C.Guerra, M. Rossmeisl, L.P. Kozak. Synergistic Gene Interactions Control the Induction of the Mitochondrial Uncoupling Protein (Ucp1) Gene in White Fat Tissue. J. Biol. Chem. 275: 34486-34492, 2000. PMID: 10931824
Koza, R.A., K. Flurkey, D.M. Graunke, C. Braun, H. Pan, P.C. Reifsnyder, L.P. Kozak and E.H. Leiter. Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity. Metabolism 53: 799-808, 2004. PMID: 15164332
Koza R.A., L. Nikonova, J. Hogan, J.S. Rim, T. Mendoza, C. Faulk, J. Skaf and L.P. Kozak. Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice. PLoS Genet 2(5): e81, 2006. PMCID: PMC1464831
Nikonova, L., R.A. Koza, T. Mendoza, P.M. Chao, J.P. Curley and L.P. Kozak. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J 22 (11): 3925-37, 2008. PMCID: PMC2574032
Koza R.A., P. Rogers and L. P. Kozak. Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation. Epigenetics 4 (7): 512-518, 2009. PMCID: PMC3951159
Kozak, L.P., S. Newman, P-M. Chao, T. Mendoza and R.A Koza. The Early Nutritional Environment of the Mouse Determines the Capacity for Adipose Tissue Expansion by Modulating Genes of Caveolae Structure. PLoS One 5(6): e11015, 2010. PMCID: PMC2888576
Doucette, CR, Horowitz MC, Berry R, MacDougald OA, Anunciado-Koza R, Koza RA,Rosen CJ. A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice. J Cell Physiol. 2015 Feb 7. doi: 10.1002/jcp.24954. [Epub ahead of print] PubMed PMID: 25663195.
Anunciado-Koza RP, Higgins DC, Koza RA. Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet. Biochimie. 2015 May 21. pii: S0300-9084(15)00141-8. doi: 10.1016/j.biochi.2015.05.007. [Epub ahead of print] PMID: 26005096