Tom Gridley, PhD
Faculty Scientist III
Center for Molecular Medicine
A complete list of publications can be found on My NCBI
Blackwood, C.A., A. Bailetti, S. Nandi, T. Gridley and J.M. Hébert. (2020) Notch Dosage: Jagged1 haploinsufficiency is associated with reduced neuronal division and disruption of periglomerular interneurons in mice. Front Cell Dev Biol. 8:113.
Peterson SM, Turner JE, Harrington A, Davis-Knowlton J, Lindner V, Gridley T, Vary CPH, Liaw L (2018) Notch2 and proteomic signatures in mouse neointimal lesion formation. Arterioscler Thromb Vasc Biol. 38:1576-1593.
Krebs, L.T., C.R. Norton and T. Gridley. (2016) Notch signal reception is required in vascular smooth muscle cells for ductus arteriosus closure. Genesis 54:86-90.
Basch, M.L., R. Brown, H.-I. Jen, F. Semerci, F. Depreux, R. Edlund, H. Zhang, C.R. Norton, T. Gridley, S. Cole, A. Doetzlhofer, M. Maletic-Savatic, N. Segil and A.K. Groves. (2016) Fringe proteins fine-tune Notch signaling to set the boundary of the organ of Corti and establish sensory cell fates. Elife:5.
Young, K., L.T. Krebs, E. Tweedie, B. Conley, M. Mancini, H. Arthur, L. Liaw, T. Gridley and C.P. Vary. (2016). Endoglin is required in Pax3-derived cells for embryonic blood vessel formation. Dev Biol. 409:95-105.
Gridley, T. (2016) Twenty years in Maine: integrating insights from developmental biology into translational medicine in a small state. Curr Top Dev Biol. 116:435-443.
Pardo-Saganta, A., P.R. Tata, B.M. Law, B. Saez, R.D. Chow, M. Prabhu, T. Gridley and J. Rajagopal. (2015) Parent stem cells can serve as niches for their daughter cells. Nature 523:597-601.
Rostama, B., J.E. Turner, G.T. Seavey, C.R. Norton, T. Gridley, C.P. Vary and L. Liaw. (2015) DLL4/Notch1 and BMP9 interdependent signaling induces human endothelial cell quiescence via P27KIP1 and Thrombospondin-1. Arterioscler Thromb Vasc Biol. 35:2626-2637.
Horvay, K., T. Jarde, F. Casagranda, V.M. Perreau, K. Haigh, C.M. Nefzger, R. Akhtar, T. Gridley, G. Berx, J.J. Haigh, N. Barker, J.M. Polo, G.R. Hime and H.E. Abud. (2015) Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO J. 34:1319-1335.
Villarejo, A., P. Molina-Ortiz, Y. Montenegro, G. Moreno-Bueno, S. Morales,V. Santos, T. Gridley, M.A. Pérez-Moreno, H. Peinado, F. Portillo, C. Calés and A. Cano. (2015) Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors. Carcinogenesis 36:585-597.
Castillo-Lluva, S., L. Hontecillas-Prieto, A. Blanco-Gómez, M. del Mar Sáez-Freire, B. García-Cenador, J. García-Criado, M. Pérez-Andrés, A. Orfao de Matos, M. Cañamero, T. Gridley, J.-H. Mao, A. Castellanos-Martín and J. Pérez-Losada. (2015) A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development. Oncogene 34:4777–4790.
Gridley, T., and A.K. Groves. (2014) Overview of genetic tools and techniques to study Notch signaling in mice. Meth Molec Biol. 1187:47-61.
Gridley, T., and S. Kajimura. (2014) Lightening up a notch: Notch regulation of energy metabolism. Nature Med. 20:811-812.
Zander, M., G.I. Cancino, T. Gridley, D.R. Kaplan and F.D. Miller (2014) The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life. PLoS One 9:e104767
Battle, R., L. Alba-Castellón, J. Loubat-Casanovas, E. Armenteros, C. Franci, J. Stanisavljevic, R. Banderas, J. Martin-Caballero, F. Bonilla, J. Baulida, J.I. Casal, T. Gridley, and A. García de Herreros. (2013) Snail1 controls TGF-β responsiveness and differentiation of Mesenchymal Stem Cells. Oncogene 32:3381-3389.
Xu, J., and T. Gridley. (2013) Notch2 is required in somatic cells for ovarian germ cell nest breakdown and primordial follicle formation. BMC Biol. 11:13.
Chen, Y., and T. Gridley. (2013) Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Min Res. 28:1412-1421.
Chen, Y., and T. Gridley. (2013) The SNAI1 and SNAI2 proteins occupy their own and each other’s promoter during chondrogenesis. Biochem Biophys Res Commun. 435:356-360.
Bradley, C.K., C.R. Norton, Y. Chen, X. Han, C.J. Booth, J.K. Yoon, L.T. Krebs and T. Gridley. (2013) The Snail family gene Snai3 is not essential for embryogenesis in mice. PLoS One 8:e65344.
Norton, C.R., Y. Chen, X. Han, C.K. Bradley, L.T. Krebs, J.K. Yoon and T. Gridley. (2013) Absence of a major role for the Snai1 and Snai3 genes in regulating skeletal muscle regeneration in mice. PLoS Curr Musc Dystrophy. doi: 10.1371/ currents.md.e495b27ee347fd3870a8316d4786fc17.